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MagnetOs for predictable fusions

A bone graft like no other

MagnetOs is a bone graft like no other: thanks to its NeedleGrip surface technology, it grows bone even in soft tissues.* This surface technology provides traction for our body’s vitally important ‘pro-healing’ immune cells (M2 macrophages).†‡1,2

This in turn, unlocks previously untapped potential to stimulate stem cells – and form new bone throughout the graft.†§3-6

The growing body of science behind NeedleGrip is called osteoimmunology. But for surgeons and their patients it means one thing: a more predictable fusion.¶5,6

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current % rate of non-unions.7,8

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current % rate of revision surgeries needed.9

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% fusion rate that can be improved by choosing the most effective bone graft.8,10,11

MagnetOs Mechanism of Action

Kuros Biosciences MagnetOs mechanism of action animation
Kuros Biosciences MagnetOs bone graft Mechanism of action Polarization

1. Polarize

Circulating immune cells (monocytes) differentiate into macrophages that are subsequently polarized, by the submicron needle-shaped features of MagnetOs’ Needlegrip surface.

As a result, they become the pro-healing, anti-inflammatory M2 macrophage phenotype.†2,6

Kuros Biosciences MagnetOs mechanism of action Regeneration

2. Regenerate

In natural bone homeostasis, it is well established that M2 macrophages play a critical role.

M2 macrophages communicate with local stem – and progenitor cells via secretion of regenerative signaling factors, including osteoactivin and BMP-2.6,12,13

These signaling factors induce mesenchymal stem cells to migrate, proliferate, and differentiate into osteoblasts that lay down osteoid.6,13-15

Endothelial cells are stimulated to form capillaries that deliver nutrients and yet more osteogenic cells to the site of repair.6,13

Kuros Biosciences MagnetOs bone graft mechanism of action Propagation

3. Propagate

Non-unions tend to happen in the core of large-span defects, as seen in spinal fusions.

NeedleGrip propagates bone in this core region – by interacting directly and indirectly with circulating osteogenic cells – rather than only from the outside-in via creeping edge repair.†‡2-5

What surgeons are saying about MagnetOs

Dr. Patel, Northwestern Center for Spine Health, Chicago, IL

Dr. Poelstra, The Rothman Institute, Jersey City, NJ

Dr. Sama, HSS Spine, New York, NY

Dr. Sandhu, MedStar Georgetown University Hospital, Washington, D.C.

Dr. Allen, UC San Diego Health, San Diego, CA

Mr. Tucker, Great Ormond St, London

Dr. Patel, Northwestern Center for Spine Health, Chicago, IL

Dr. Poelstra, The Rothman Institute, Jersey City, NJ

Dr. Sama, HSS Spine, New York, NY

Dr. Sandhu, MedStar Georgetown University Hospital, Washington, D.C.

Dr. Allen, UC San Diego Health, San Diego, CA

Mr. Tucker, Great Ormond St, London

MagnetOs:
the evidence

MagnetOs is proven to be equivalent to the gold standard of autograft for spinal fusions.2,4,5 It has been used in more than 15,000 fusion surgeries to date, and is supported by an unprecedented blend of scientific, pre-clinical and clinical studies through Project Fusion: our global research program, where science and clinical evidence meet.

Kuros is the first and only company to reliably translate evidence from benchtop through to patient. Watch these 5 videos to see how.

MagnetOs, Vitoss® and Novabone® in a multi-endpoint, clinically-relevant ovine model of posterolateral spinal fusion

Van Dijk et al. Clin Spine Surg. 2020; 33(6):E276-E287.

This study reveals clear differences in efficacy between commercially-available bone grafts.

MagnetOs was the only bone graft to show equivalent histological, biomechanical and radiological fusion to autograft.

Submicron topography of MagnetOs promotes bone formation in soft tissues of canines without added cells or growth factors

Duan et al. Eur Cell Mater. 2019;28;37:60-73.

With its unique submicron topography, MagnetOs is able to induce the formation of bone in soft tissues of canines without added cells or growth factors.

MagnetOs vs. Autograft in a clinically-relevant ovine model of posterolateral fusion

Van Dijk et al. JOR Spine. 2018;e1039.

Equivalent fusion outcomes for MagnetOs and autograft were found across histological, biomechanical and radiological endpoints.

Efficacy of MagnetOs bone graft in a lapine posterolateral spinal fusion model

Van Dijk et al. J Biomed Mater Res. Part B: Appl Biomater. 2019; 107(6):2080-2090.

This data demonstrates that, as bone graft extenders, MagnetOs Granules and MagnetOs Putty are equivalent to autograft in achieving posterolateral spinal fusion.

In vitro upregulation of M2 macrophages

Van Dijk et al.

With its unique submicron surface topography, MagnetOs polarizes naive human-derived monocytes to the pro-healing, anti-inflammatory phenotype of macrophage.

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