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MagnetOs has achieved nearly twice the fusion rate of autograft in the latest level 1 clinical trial.1

1 Stempels, H., et al. "Efficacy of biphasic calcium phosphate ceramic with a needle-shaped surface topography versus autograft in instrumented posterolateral spinal fusion: A randomized trial." Spine. June 17, 2024 https://doi.org/10.1097/BRS.0000000000005075.

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MagnetOs for predictable fusions

A bone graft like no other

MagnetOs is a bone graft like no other: thanks to its NeedleGrip surface technology, it grows bone even in soft tissues.* This surface technology provides traction for our body’s vitally important ‘pro-healing’ immune cells (M2 macrophages).†‡1,2

This in turn, unlocks previously untapped potential to stimulate stem cells – and form new bone throughout the graft.†§3-6

The growing body of science behind NeedleGrip is called osteoimmunology. But for surgeons and their patients it means one thing: a more predictable fusion.¶5,6

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current % rate of non-unions.7,8

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current % rate of revision surgeries needed.9

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% fusion rate that can be improved by choosing the most effective bone graft.8,10,11

MagnetOs Mechanism of Action

Kuros Biosciences MagnetOs mechanism of action animation
Kuros Biosciences MagnetOs bone graft Mechanism of action Polarization

1. Polarize

Circulating immune cells (monocytes) differentiate into macrophages that are subsequently polarized, by the submicron needle-shaped features of MagnetOs’ Needlegrip surface.

As a result, they become the pro-healing, anti-inflammatory M2 macrophage phenotype.†2,6

Kuros Biosciences MagnetOs mechanism of action Regeneration

2. Regenerate

In natural bone homeostasis, it is well established that M2 macrophages play a critical role.

M2 macrophages communicate with local stem – and progenitor cells via secretion of regenerative signaling factors, including osteoactivin and BMP-2.6,12,13

These signaling factors induce mesenchymal stem cells to migrate, proliferate, and differentiate into osteoblasts that lay down osteoid.6,13-15

Endothelial cells are stimulated to form capillaries that deliver nutrients and yet more osteogenic cells to the site of repair.6,13

Kuros Biosciences MagnetOs bone graft mechanism of action Propagation

3. Propagate

Non-unions tend to happen in the core of large-span defects, as seen in spinal fusions.

NeedleGrip propagates bone in this core region – by interacting directly and indirectly with circulating osteogenic cells – rather than only from the outside-in via creeping edge repair.†‡2-5

What surgeons are saying about MagnetOs

Dr. Patel, Northwestern Center for Spine Health, Chicago, IL

Dr. Poelstra, The Rothman Institute, Jersey City, NJ

Dr. Sama, HSS Spine, New York, NY

Dr. Sandhu, MedStar Georgetown University Hospital, Washington, D.C.

Dr. Allen, UC San Diego Health, San Diego, CA

Mr. Tucker, Great Ormond St, London

Dr. Patel, Northwestern Center for Spine Health, Chicago, IL

Dr. Poelstra, The Rothman Institute, Jersey City, NJ

Dr. Sama, HSS Spine, New York, NY

Dr. Sandhu, MedStar Georgetown University Hospital, Washington, D.C.

Dr. Allen, UC San Diego Health, San Diego, CA

Mr. Tucker, Great Ormond St, London

MagnetOs:
the evidence

MagnetOs is proven to be equivalent to the gold standard of autograft for spinal fusions.2,4,5,16 It has been used in more than 25,000 fusion surgeries to date and is supported by an unprecedented blend of scientific, pre-clinical and clinical studies through Project Fusion: our global research program, where science and clinical evidence meet.

Kuros is dedicated to reliably translate evidence from benchtop through to patient. To see how, review our extensive list of studies including peer-reviewed results from our latest Level I clinical trial published in Spine.16

Level I Clinical Evidence: MAXA

A randomized, intra-patient controlled trial of MagnetOs Granules versus autograft in instrumented posterolateral spinal fusion

Peer-reviewed research paper published in Spine (June 2024)16

Want to learn more about MagnetOs?

Book your own appointment with one of our scientific experts.