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Project Fusion: where Science and Clinical Evidence meet

Making the unpredictable… predictable

Today, nearly 1 in 5 spinal fusions fail. So, what can we do to change this situation – for the benefit of patients, surgeons and our wider society?

This is the question that drives us at Kuros. Every day our team works across three continents to unlock the hidden secrets of bone healing through our research, development & technology program: Project Fusion.

To deliver the ideal bone graft, we believe you need the highest quality & quantity of scientific evidence behind it. Which is why Project Fusion brings together an unprecedented blend of scientific, preclinical and clinical studies – all aimed at making the unpredictable…predictable.

The goals of Project Fusion

Data

Translating evidence from benchtop through to patients with proven clinical outcomes. We are developing a clinical data package that is superior to any other bone graft cleared for use via the same regulatory pathway.

Expertise

Enlightening spine surgeons about the importance of osteoimmunology through robust and peer-reviewed science and educational resources.

The evidence is clear

How are we translating the benefits of Project Fusion? We are generating a clinical data package that is superior to any other bone graft cleared for use via the same regulatory pathway. This includes:

10

clinical trials initiated.

>25

patents granted.

>320

scientific papers published.

>25000

patients treated.

Level 1

Clinical Evidence

Level I, prospective, randomized controlled trials

Level I: MAXA

A randomized, intra-patient controlled trial of MagnetOs Granules versus autograft in instrumented posterolateral spinal fusion

Peer-reviewed publication coming soon.

Level I: PROOF (Ongoing)

A prospective, randomized, multi-center study of MagnetOs Putty compared to DBM mixed with autograft in patients undergoing up to two-level instrumented posterolateral lumbar fusion

ClinicalTrials.gov Identifier: NCT04679844

Level I: PRECISE (Ongoing)

A prospective, randomized, multi-center study to assess the performance of MagnetOs Flex Matrix compared to a cell based allograft in patients undergoing up to four-level instrumented posterolateral lumbar fusion

ClinicalTrials.gov Identifier: NCT05037968

Additional

Clinical Evidence

Retrospective trials, case studies and white papers

Retrospective: Lumbar Interbodies ALIF/LLIF, 49% High Risk-Patient Cohort, MagnetOs

Biphasic calcium phosphate bone graft with a unique surface topography: A single-center ambispective study for degenerative disease of the lumbar spine

P. Nunley. Cureus. 2024;16(4): e58218.

Retrospective: Foot and Ankle, MagnetOs Putty

Arthrodesis of the subtalar joint using a novel biphasic calcium phosphate bone graft

T. Fusco. Foot and Ankle Surgery: Techniques, Reports & Cases. 2022;2(1).

Case Series: PLF, MagnetOs Granules and Putty

Effective use of a novel biphasic calcium phosphate with submicron surface topography in posterolateral spine fusion

A. Jones. JOJ Case Stud. 2021;12(2).

Case Series: PLF, MagnetOs Granules

Posterior thoracolumbar hemivertebra resection and fusion with a biphasic calcium phosphate bone graft with a novel submicron surface topography

F. Sandhu. JOJ Case Stud. 2021;12(2).

Case Series: Foot and Ankle, MagnetOs Granules and Putty

Clinical, radiographic, and histologic outcomes of ankle arthrodesis in a diabetic patient using a biphasic calcium phosphate bone graft with a novel submicron needle-shaped surface topography

T. Fusco. JOJ Case Stud. 2022;13(2).

Whitepaper: PLF, MagnetOs Putty

Use of a novel biphasic calcium phosphate with submicron surface topography as an extender to autograft in posterolateral spinal fusion

UCSD Orthopedic Surgery Department, CA

Preclinical Evidence

Scientific studies

Preclinical: Ovine, MagnetOs Putty

MagnetOs, Vitoss® and Novabone® in a multi-endpoint, clinically-relevant ovine model of posterolateral spinal fusion

van Dijk et al. Clin Spine Surg. 2020; 33(6):E276-E287.

Preclinical: Canine, MagnetOs Granules

Accelerated bone formation by biphasic calcium phosphate with a novel sub-micron surface topography promotes bone formation in soft tissues of canines without added cells or growth factors

Duan et al. Eur Cell Mater. 2019;28;37:60-73.

Preclinical: Ovine, MagnetOs Granules and Putty

Biphasic calcium phosphate with submicron surface topography in an ovine model of instrumented posterolateral spinal fusion

van Dijk et al. JOR Spine. 2018;e1039.

Preclinical: Lapine, MagnetOs Granules and Putty

Efficacy of a synthetic calcium phosphate with submicron surface topography as autograft extender in lapine posterolateral spinal fusion

van Dijk et al. J Biomed Mater Res. Part B: Appl Biomater. 2019; 107(6):2080-2090.

Scientific: In vitro, MagnetOs Granules

Calcium phosphate with submicron topography influences primary human macrophage response, enhancing downstream angiogenesis and osteogenesis in vitro

van Dijk et al. Journal of Immunology and Regenerative Medicine. 2023; 19 (2023).

Meet the Expert

Are you a surgeon that would like to understand more about how the body’s immune system can be modulated to eliminate non-unions? Simply book a slot with one of our scientists or surgeons below. Once signed up, you will receive an email confirming your appointment and how to join the online meeting. We look forward to speaking with you!

Want a downloadable and comprehensive document detailing all of our research papers?

Request our Global Research Summary!