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Pioneering solutions for targeted and controlled bone healing

Join us in our mission to eliminate non-unions and improve patient rehabilitation

Our aim is to deliver decreased complications, advanced functional rehabilitation and to eliminate non-unions for spine surgeons and their patients

Our contribution

With more than 150 years of combined research experience, we feel well-established as leaders in orthobiologics, but we’re never content with resting on our laurels. Instead, we continue to forge beyond the accepted solutions for spinal fusion. Our focus is on revolutionizing the field of orthobiologics by developing bone grafts that deliver both targeted and controlled bone healing.

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Pioneering technology

We recently launched MagnetOs, a unique bone graft with submicron surface topography, that harnesses the power of osteoimmunology to deliver uniform, solid and stable spinal fusions.

The U.S. Food and Drug Administration (FDA) has approved an IND for the investigation of our Fibrin-PTH (KUR-113) product candidate; the first ever drug-biologic combination for spinal interbody fusion. Fibrin-PTH (KUR-113) is entering a Phase 2a clinical trial in the U.S.

Strategic Advisory Board

Dr Alpesh A. Patel, MD, FACS Dr Alpesh A. Patel, MD, FACS
Alpesh A. Patel, MD is the Director of Orthopedic Spine Surgery at Northwestern and a spine surgeon with fellowship training in both Orthopedic Spine Surgery and Neurosurgery. Dr. Patel specializes in cervical spine surgery and minimally invasive spine surgery.
Dr Alpesh A. Patel, MD, FACS

Director of Orthopedic Spine Surgery, Northwestern Medicine, Chicago, IL

Dr Andrew A. Sama, MD Dr Andrew A. Sama, MD
Andrew Sama, MD is Co-Chief of HSS Spine where he specializes in the management of all traumatic, degenerative, and deformity-related conditions of the cervical, thoracic, and lumbosacral spine. Dr. Sama also serves as an Associate Professor of Clinical Surgery, Weill Medical College of Cornell University.
Dr Andrew A. Sama, MD

Co-Chief of HSS Spine, New York, NY

Dr Kornelis Poelstra, MD, PhD Dr Kornelis Poelstra, MD, PhD
Kornelis Poelstra is board certified in orthopedic spine surgery. He specializes primarily in long-construct minimally invasive spine surgeries, adult spinal deformity, oncologic conditions, spinal fracture treatment and cervical disc replacements. He is one of the world leaders in Robotic Spine Surgery.
Dr Kornelis Poelstra, MD, PhD

Orthopedic Spine Surgeon, OrthoNorthCal, Los Gatos, CA

Prof. Bill Walsh PhD Prof. Bill Walsh PhD
W.R. Walsh, PhD is a Professor in the Prince of Wales Clinical School, Division of Surgery at University of New South Wales in Sydney, Australia, and Director of Surgical & Orthopaedic Research Laboratories, Prince of Wales Hospital. His research lies at the interface between implanted materials and the connective tissues of the body.
Prof. Bill Walsh PhD

Professor, Division of Surgery at University of New South Wales, Sydney, Australia

Dr Faheem Sandhu, MD, PhD Dr Faheem Sandhu, MD, PhD
Faheem Sandhu, MD, PhD, is Director of Spine Surgery at MedStar Georgetown University Hospital and Professor of Neurological Surgery at Georgetown University Medical Center. He specializes in minimally invasive and complex spinal surgery.
Dr Faheem Sandhu, MD, PhD

Director of Spine Surgery, MedStar Georgetown University Hospital, Chevy Case, MD

Dr R. Todd Allen, MD, PhD Dr R. Todd Allen, MD, PhD
Richard (Todd) Allen, MD, is board-certified orthopedic surgeon with expertise in complex adult reconstruction procedures for deformity/scoliosis and tumors. He also specializes in complex disorders of the upper cervical spine and in degenerative, traumatic, and post-traumatic conditions.
Dr R. Todd Allen, MD, PhD

Associate Professor of Orthopaedic Surgery, UC San Diego Health, San Diego, CA

Learning Hub

Visit our free Learning Hub to learn how to eliminate non-unions and improve patient rehabilitation

Meet the Expert

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Deep Dives for Distributors

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Inspirational Coffee Chats

Join 30 minute virtual sessions with spine surgeons

Our latest Coffee Chat

Surface Technologies: What is their Relevance to Fusion?

In this edition, Dr. Sigurd Berven and Dr. Todd Allen discuss the evolution of surface technology its impact on bone grafts and spinal implants.

Dr. Todd Allen and Dr. Sigurd Berven

MagnetOs

MagnetOs is an advanced bone graft with a porous trabecular structure that mimics human cancellous bone and a unique submicron surface topography that harnesses the power of macrophage polarization and osteoimmunology to form bone instead of scar tissue.3*

This effect is so potent that MagnetOs can form bone in soft tissues without added cells or growth factors,4*¥ meaning in preclinical studies bone is formed simultaneously throughout posterolateral spine defects.1,2,5

Watch to find out how its needle-shaped submicron feature promotes attachment and spreading of macrophages, leading to uniform, solid and stable spine fusions.1-3*

No added cells or growth factors

In preclinical studies, MagnetOs has been shown to direct bone formation even in soft tissue, without the need for added cells or growth factors.4*¥

“Gold Standard” fusion

Using clinically-relevant animal models, multiple fusion endpoint analysis at the 12-week mark showed MagnetOs’ performance was equivalent to autograft, the gold standard.2,3*

Best in class

In validated preclinical tests, MagnetOs is radiographically, biomechanically and histologically superior to the category leaders Vitoss BA2X and Novabone Putty.5*

Fibrin-PTH

Our Fibrin-PTH technology, is based on the well-established mechanism of action of parathyroid hormone – or PTH as it is commonly known – and the natural healing matrix fibrin.

It promotes controlled bone formation at the site of implantation through the induction of osteoprogenitor cell differentiation, enhancement of osteoblast proliferation and by increasing the life-span of bone-forming cells.6*

Fibrin-PTH (KUR-113) is the first ever investigational drug-biologic product candidate being evaluated for spinal fusion.#

Comparable efficacy to rhBMP-2

Demonstrated for Fibrin-PTH (KUR-113) in preclinical animal studies of spinal fusion.7*#

Easy to use

Excellent flowability and setting properties for Fibrin-PTH (KUR-113) shown in preclinical studies.8*#

Clinical experience

Effective for bone healing with a promising safety profile in two Phase 2 orthopedic trauma trials.9,10

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