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Product information on this website is intended only for healthcare professionals and medical devices distributors. This website may contain general information relating to medical conditions and their treatment. Such information is provided for informational purposes only and is not meant to be a substitute for advice provided by a doctor or other qualified health care professional. If you are a patient or carer of a patient please consult your doctor for professional medical advice.
Our aim is to deliver decreased complications, advanced functional rehabilitation and to eliminate non-unions for spine surgeons and their patients
With more than 150 years of combined research experience, we feel well-established as leaders in orthobiologics, but we’re never content with resting on our laurels. Instead, we continue to forge beyond the accepted solutions for spinal fusion. Our focus is on revolutionizing the field of orthobiologics by developing bone grafts that deliver both targeted and controlled bone healing.FIND OUT MORE
We recently launched MagnetOs, a unique bone graft with submicron surface topography, that harnesses the power of osteoimmunology to deliver uniform, solid and stable spinal fusions.
The U.S. Food and Drug Administration (FDA) has approved an IND for the investigation of our Fibrin-PTH (KUR-113) product candidate; the first ever drug-biologic combination for spinal interbody fusion. Fibrin-PTH (KUR-113) has entered a Phase 2 clinical trial in the U.S.
Alpesh A. Patel, MD is the Director of Orthopedic Spine Surgery at Northwestern and a spine surgeon with fellowship training in both Orthopedic Spine Surgery and Neurosurgery. Dr. Patel specializes in cervical spine surgery and minimally invasive spine surgery.
Director of Orthopedic Spine Surgery, Northwestern Medicine, Chicago, IL
Andrew Sama, MD is Co-Chief of HSS Spine where he specializes in the management of all traumatic, degenerative, and deformity-related conditions of the cervical, thoracic, and lumbosacral spine. Dr. Sama also serves as an Associate Professor of Clinical Surgery, Weill Medical College of Cornell University.
Co-Chief of HSS Spine, New York, NY
Kornelis Poelstra is board certified in orthopedic spine surgery. He specializes primarily in long-construct minimally invasive spine surgeries, adult spinal deformity, oncologic conditions, spinal fracture treatment and cervical disc replacements. He is one of the world leaders in Robotic Spine Surgery.
Orthopedic Spine Surgeon, OrthoNorthCal, Los Gatos, CA
W.R. Walsh, PhD is a Professor in the Prince of Wales Clinical School, Division of Surgery at University of New South Wales in Sydney, Australia, and Director of Surgical & Orthopaedic Research Laboratories, Prince of Wales Hospital. His research lies at the interface between implanted materials and the connective tissues of the body.
Professor, Division of Surgery at University of New South Wales, Sydney, Australia
Faheem Sandhu, MD, PhD, is Director of Spine Surgery at MedStar Georgetown University Hospital and Professor of Neurological Surgery at Georgetown University Medical Center. He specializes in minimally invasive and complex spinal surgery.
Director of Spine Surgery, MedStar Georgetown University Hospital, Chevy Case, MD
Richard (Todd) Allen, MD, is board-certified orthopedic surgeon with expertise in complex adult reconstruction procedures for deformity/scoliosis and tumors. He also specializes in complex disorders of the upper cervical spine and in degenerative, traumatic, and post-traumatic conditions.
Associate Professor of Orthopaedic Surgery, UC San Diego Health, San Diego, CA
Visit our free Learning Hub to learn how to eliminate non-unions and improve patient rehabilitation
During this 10 minute session presented at the NASS 2020 Annual meeting, Dr Richard Todd Allen, MD, PhD, Associate Professor and spine surgeon at UC San Diego Health, shares his clinical experience of MagnetOs bone graft. Dr Allen has been using MagnetOs in his spine fusion patients for over a year and recently performed the first-ever implantation of Kuros’ Fibrin-PTH in the STRUCTURE Phase 2 clinical trial.
MagnetOs is an advanced bone graft with a porous trabecular structure that mimics human cancellous bone and a unique submicron surface topography that harnesses the power of macrophage polarization and osteoimmunology to form bone instead of scar tissue.3*
This effect is so potent that MagnetOs can form bone in soft tissues without added cells or growth factors,4*¥ meaning in preclinical studies bone is formed simultaneously throughout posterolateral spine defects.1,2,5
Watch to find out how its needle-shaped submicron feature promotes attachment and spreading of macrophages, leading to uniform, solid and stable spine fusions.1-3*
In preclinical studies, MagnetOs has been shown to direct bone formation even in soft tissue, without the need for added cells or growth factors.4*¥
Using clinically-relevant animal models, multiple fusion endpoint analysis at the 12-week mark showed MagnetOs’ performance was equivalent to autograft, the gold standard.2,3*
In validated preclinical tests, MagnetOs is radiographically, biomechanically and histologically superior to the category leaders Vitoss BA2X and Novabone Putty.5*
Our Fibrin-PTH technology, is based on the well-established mechanism of action of parathyroid hormone – or PTH as it is commonly known – and the natural healing matrix fibrin.
It promotes controlled bone formation at the site of implantation through the induction of osteoprogenitor cell differentiation, enhancement of osteoblast proliferation and by increasing the life-span of bone-forming cells.6*
Fibrin-PTH (KUR-113) is the first ever investigational drug-biologic product candidate being evaluated for spinal fusion.#
Demonstrated for Fibrin-PTH (KUR-113) in preclinical animal studies of spinal fusion.7*#
Excellent flowability and setting properties for Fibrin-PTH (KUR-113) shown in preclinical studies.8*#
Effective for bone healing with a promising safety profile in two Phase 2 orthopedic trauma trials.9,10
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