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Project Fusion: where Science and Clinical Evidence meet
Making the unpredictable… predictable
Today, nearly 1 in 5 spinal fusions fail. So, what can we do to change this situation – for the benefit of patients, surgeons and our wider society?
This is the question that drives us at Kuros. Every day our team works across three continents to unlock the hidden secrets of bone healing through our research, development & technology program: Project Fusion.
To deliver the ideal bone graft, we believe you need the highest quality & quantity of scientific evidence behind it. Which is why Project Fusion brings together an unprecedented blend of scientific, preclinical and clinical studies – all aimed at making the unpredictable…predictable.
The goals of Project Fusion
The evidence is clear
How are we translating the benefits of Project Fusion? We are generating a clinical data package that is superior to any other bone graft cleared for use via the same regulatory pathway. This includes:
10
clinical trials initiated.
>25
patents granted.
>320
scientific papers published.
>25000
patients treated.
Level 1
Clinical Evidence
Level I, prospective, randomized controlled trials
Level I: MAXA
A randomized, intra-patient controlled trial of MagnetOs Granules versus autograft in instrumented posterolateral spinal fusion
Peer-reviewed publication coming soon.
Level I: PROOF (Ongoing)
A prospective, randomized, multi-center study of MagnetOs Putty compared to DBM mixed with autograft in patients undergoing up to two-level instrumented posterolateral lumbar fusion
ClinicalTrials.gov Identifier: NCT04679844
Level I: PRECISE (Ongoing)
A prospective, randomized, multi-center study to assess the performance of MagnetOs Flex Matrix compared to a cell based allograft in patients undergoing up to four-level instrumented posterolateral lumbar fusion
ClinicalTrials.gov Identifier: NCT05037968
Additional
Clinical Evidence
Retrospective trials, case studies and white papers
Retrospective: Foot and Ankle, MagnetOs Putty
Arthrodesis of the subtalar joint using a novel biphasic calcium phosphate bone graft
T. Fusco. Foot and Ankle Surgery: Techniques, Reports & Cases. 2022;2(1).
Case Series: PLF, MagnetOs Granules and Putty
Effective use of a novel biphasic calcium phosphate with submicron surface topography in posterolateral spine fusion
A. Jones. JOJ Case Stud. 2021;12(2).
Case Series: PLF, MagnetOs Granules
Posterior thoracolumbar hemivertebra resection and fusion with a biphasic calcium phosphate bone graft with a novel submicron surface topography
F. Sandhu. JOJ Case Stud. 2021;12(2).
Case Series: Foot and Ankle, MagnetOs Granules and Putty
Clinical, radiographic, and histologic outcomes of ankle arthrodesis in a diabetic patient using a biphasic calcium phosphate bone graft with a novel submicron needle-shaped surface topography
T. Fusco. JOJ Case Stud. 2022;13(2).
Whitepaper: PLF, MagnetOs Putty
Use of a novel biphasic calcium phosphate with submicron surface topography as an extender to autograft in posterolateral spinal fusion
UCSD Orthopedic Surgery Department, CA
Preclinical Evidence
Scientific studies
Preclinical: Ovine, MagnetOs Putty
MagnetOs, Vitoss® and Novabone® in a multi-endpoint, clinically-relevant ovine model of posterolateral spinal fusion
van Dijk et al. Clin Spine Surg. 2020; 33(6):E276-E287.
Preclinical: Canine, MagnetOs Granules
Submicron topography of MagnetOs promotes bone formation in soft tissues of canines without added cells or growth factors
Duan et al. Eur Cell Mater. 2019;28;37:60-73.
Preclinical: Ovine, MagnetOs Granules and Putty
MagnetOs vs. autograft in a clinically-relevant ovine model of posterolateral fusion
van Dijk et al. JOR Spine. 2018;e1039.
Preclinical: Lapine, MagnetOs Granules and Putty
Efficacy of MagnetOs bone graft in a lapine posterolateral spinal fusion model
van Dijk et al. J Biomed Mater Res. Part B: Appl Biomater. 2019; 107(6):2080-2090.
Scientific: In vitro, MagnetOs Granules
Calcium phosphate with submicron topography influences primary human macrophage response, enhancing downstream angiogenesis and osteogenesis in vitro
van Dijk et al. Journal of Immunology and Regenerative Medicine. 2023; 19 (2023).
Meet the Expert
Are you a surgeon that would like to understand more about how the body’s immune system can be modulated to eliminate non-unions? Simply book a slot with one of our scientists or surgeons below. Once signed up, you will receive an email confirming your appointment and how to join the online meeting. We look forward to speaking with you!
Want a downloadable and comprehensive document detailing all of our studies?
Request our Global Research Summary.
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