MagnetOs Granules

MagnetOs™ Granules is the original form of our advanced bone graft based on the submicron needle-shaped NeedleGrip™ surface technology. It remains the foundation of the MagnetOs formulations and is the driver of our mechanism of action for bone generation in the extremities.^†1-3

Evidence isn’t optional for Kuros. We are committed to generating high-quality evidence, enabling our team to discover, develop and deliver innovative biologic technologies with one goal in mind: To give surgeons the confidence to make evidence-based decisions for their patients.

These novel innovations have revealed a powered mechanism of action for bone growth, offering tremendous promise for predictable fusions and traumatic reconstructions of the extremity.

Handling​

Packaged in granule form without any carrier, MagnetOs Granules lends itself to growing bone in amorphous and contained or semi-contained voids.⁴
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Proven Foundation

MagnetOs Granules are the basis for all MagnetOs formulations and have been CE-marked since 2017. This foundational technology is supported by an unprecedented blend of scientific, preclinical, and clinical studies through our global research program, Project Fusion.
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Harnessing the immune system ​

MagnetOs is capable of polarizing macrophages from the M1 pro-inflammatory to the M2 pro-healing phenotype, which is known to influence bone growth through secretion of proteins such as BMP-2. Pre-clinical studies have demonstrated the osteoinductive potential of MagnetOs  without added cells or growth factors.^*†‡1-3

These features combine to make MagnetOs an active player in providing predictable joint fusions and traumatic reconstructions of the extremity.
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Equivalent to autograft ​

In fact, MagnetOs Granules as a standalone bone graft reached higher fusion rates than the gold standard of autograft. This is based on results of an observer blinded, randomized, controlled, intrapatient, multi-center clinical trial of instrumented posterolateral fusions of the spine, as assessed by fine-cut CT scans at one year follow-up.^5​

The MagnetOs Granules technology is also proven to be equivalent to autograft for spinal fusions in multiple pre-clinical models.^*†‡#1-3