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Early Radiographic and Clinical Outcomes of Five Patients Undergoing Open Instrumented Posterolateral Fusion Surgery with MagnetOs Flex Matrix
Abstract: One important factor in obtaining bony fusion in open posterolateral arthrodesis surgery is the bone graft chosen for the procedure. The gold standard is autograft bone in the form of Iliac Crest Bone Graft, but with limited supply and co-morbidities related to harvesting, surgeons have investigated alternative options. One alternative is synthetic calcium phosphate, which is increasingly used in place of autograft because of its efficacy, reasonable cost, low incidence of adverse reactions, and reduced need to harvest large amounts of autologous bone. MagnetOs Flex Matrix is a collagen containing synthetic biphasic calcium phosphate bone graft which harnesses the power of osteoimmunology through its NeedleGrip surface topography. This surface topography polarizes macrophages to the M2 pro-healing phenotype, which in turn signals to mesenchymal stem cells to differentiate to osteoblasts and promote bone growth. Traditionally, collagen containing bone grafts are made with a tightly crosslinked type one collagen that takes 6-8 weeks to resorb once implanted. Kuros Biosciences invented MagnetOs Flex Matrix with an open fibrillar network of type one collagen made to reduce the collagen resorption time and increase the surface area of the bone graft. An open fibrillar collagen allows the surface features of the MagnetOs Granules to be exposed to the host tissue. This case series reviews five lumbar and cervical posterolateral spinal fusions in a challenging patient population. In each of the cases there was evidence of fusion at early timepoints, with radiographic signs including bony bridging, evidence of trabecular bone, and cortical ridges at the fusion site. Additionally, all of the patients reported improvement in patient reported outcome scores when utilizing MagnetOs Flex Matrix.
Citation: Goodmanson R, Butrico C, Sage K. Early Radiographic and Clinical Outcomes of Five Patients Undergoing Open Instrumented Posterolateral Fusion Surgery with MagnetOs Flex Matrix. JOJ Case Stud. 2023; 14(3): 555886. DOI: 10.19080/JOJCS.2023.14.555886.
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