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MagnetOsTM: Osteoinductive by design.
Powered by NeedleGrip™ surface technology.
MagnetOs bone graft is osteoinductive by design through NeedleGrip, our propietary submicron surface technology that harnesses the immune system to stimulate bone growth without added cells or growth factors.*1-3
What is osteoinduction?
Osteoinduction refers to the recruitment and differentiation of stem cells into bone-forming cells, often demonstrated in preclinical studies by a graft’s ability to induce bone formation when implanted in an animal muscle pouch model.4,5
In short, osteoinduction means the graft induces new bone formation on its own.4,5
Most bone graft substitutes are only osteoconductive – they provide a scaffold and rely on the body’s existing biology to grow bone.
MagnetOs: Osteoinduction driven by surface architecture*1,2
MagnetOs is an advanced biphasic calcium phosphate bone graft which has demonstrated to be osteoinductive by design, thanks to NeedleGrip, a submicron surface technology that harnesses the immune system via macrophage polarization to stimulate bone growth.*1-3
M1 pro-inflammatory pathway: macrophages polarize to the M1 phenotype, which are pro-inflammatory and promote fibroblast proliferation, often leading to scar tissue.6
M2 pro-healing pathway: macrophages polarize to the M2 phenotype, which are pro-healing and upregulate stem cells to create bone.6,7 MagnetOs NeedleGrip surface technology has been shown in preclinical studies to enhance the pathway to M2 macrophages.*1,7
MagnetOs: Unique mechanism, safety by design
MagnetOs induces bone growth through a physical mechanism, not a biochemical one. Where BMP-based options rely on exogenous growth factors, and allografts on donor variability, MagnetOs surface technology, NeedleGrip, harnesses the immune system through surface topography alone.*1-3
This makes MagnetOs a predictable and trusted alternative for achieving osteoinduction, without the safety risks of growth factors and allografts.1,2,8
FAQs
What is osteoinduction?
Osteoinduction is a bone formation process that involves recruitment and subsequent differentiation of the patient’s stem cells into bone-forming cells, ultimately resulting into bone formation.4,5
MagnetOs demonstrated bone growth after implantation of MagnetOs Granules standalone in the muscle pouch of a canine model, an area isolated from bone cells.*1-3
How is osteoinduction different from osteoconduction?
Osteoinduction is the ability to actively attract and differentiate stem cells to form new bone, while osteoconduction acts as a passive physical scaffold for existing bone cells to grow across. NeedleGrip surface technology makes MagnetOs both osteoinductive and osteoconductive and so has been indicated in the Instructions for Use (IFU).4,5
Which types of bone grafts are osteoinductive?
Osteoinduction is the recruitment and differentiation of stem cells into bone-forming cells. Two mechanisms can trigger it:
Biochemical pathway – relies on exogenous growth factors or donor cell signaling:
- Bone Morphogenetic Proteins (BMP-2, BMP-7)
- Demineralized Bone Matrix (DBM), which contains low concentrations of BMPs.
- Autograft (patient’s own harvested bone)
Physical pathway – Advanced synthetics with submicron surface technology can trigger bone growth through topography alone:
- MagnetOs with NeedleGrip*1-3
Who does osteoinduction help?
Osteoinductivity can help anyone undergoing surgery that requires a bone graft substitute. Because MagnetOs is synthetic, it also removes concerns related to tissue-derived products.9,10
What complications does it help prevent?
An osteoinductive graft may improve fusion outcomes after implantation, preventing nonunion or malunions of the bone – complications that can otherwise lead to revision surgery with the associated risks.11
What indications is osteoinduction relevant for?
All of them – the osteoinduction property can improve fusion outcomes regardless of the indication. MagnetOs bone graft is approved as an osteoinductive and osteoconductive graft, indicated for use in spine and extremities, as well as maxillofacial and pelvis.9,10
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§The content referencing MagnetOs provided herein is intended solely for the markets where MagnetOs Putty and MagnetOs Granules are CE-marked. Information presented may not apply to other regions or countries and should not be interpreted as such. *Results from in vivo or in vitro laboratory testing may not be predictive of clinical experience in humans. For important safety and intended use information please visit kurosbio.com/eifu. †Statistical analysis of radiographic fusion data determined that MagnetOs was noninferior to autograft and even indicated the superiority of MagnetOs to autograft in terms of radiographic fusion. ‡19 of the initial 100 patients were active smokers. Radiographic fusion data of the smoker subgroup were not statistically analysed as a subgroup and were not included in the peer-reviewed publication of the study. [10]
References: 1. Van Dijk, et al. eCM. 2021;41:756-73. 2. Van Dijk, et al. J Immunol Regen Med. 2023;19:100070. 3. Duan, et al. eCM. 2019;37:60-73. 4. Barradas, et al. eCM 2011;21:407-429. 5. Urist. Science 1965;150(3698):893-899. 6. Smigiel KS, et al. Curr Rheumatol Rep. 2018;20:17. 7. Loi, et al. Stem Cell Res Ther. 2016;7:15. 8. Data on file. MagnetOs Putty. 9. Instructions for Use (IFU) MagnetOs Putty. 10. Instructions for Use (IFU) MagnetOs Granules. 11. Stempels, et al. Spine. 2024;49(19):1323-1331. 12. Liguori, et al. Cell Mol Immunol. 2021;18(3):711–722. 13. Zhang, et al. Cell Tissue Res. 2017. 14. Arosarena, et al. J Cell Physiol. 2011;226(11):2943–2952.
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